InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ppp2r1a

Summary

InnateDB Protein

IDBP-141716.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ppp2r1a

Protein Name

protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform

Synonyms

6330556D22Rik; PP2A; PR65;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000007708

InnateDB Gene

IDBG-141714 (Ppp2r1a)

Protein Structure

UniProt Annotation

Function

The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Required for proper chromosome segregation and for centromeric localization of SGOL1 in mitosis (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Chromosome, centromere {ECO:0000250}. Note=Centromeric localization requires the presence of BUB1. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 162 interaction(s) predicted by orthology.

Experimentally validated
Total	41 [view]
Protein-Protein	41 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	162 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003823	antigen binding
GO:0004722	protein serine/threonine phosphatase activity
GO:0005488	binding
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0007059	chromosome segregation
GO:0070262	peptidyl-serine dephosphorylation
GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand