InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: B3gat3

Summary

InnateDB Protein

IDBP-141755.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

B3gat3

Protein Name

beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)

Synonyms

2810405M13Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000093962

InnateDB Gene

IDBG-141753 (B3gat3)

Protein Structure

UniProt Annotation

Function

Glycosaminoglycans biosynthesis. Involved in forming the linkage tetrasaccharide present in heparan sulfate and chondroitin sulfate. Transfers a glucuronic acid moiety from the uridine diphosphate-glucuronic acid (UDP-GlcUA) to the common linkage region trisaccharide Gal-beta-1,3-Gal-beta-1,4-Xyl covalently bound to a Ser residue at the glycosaminylglycan attachment site of proteoglycans. Can also play a role in the biosynthesis of l2/HNK-1 carbohydrate epitope on glycoproteins (By similarity). {ECO:0000250}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in heart, aorta, bone, and also in osteoblasts. {ECO:0000269PubMed:21763480}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015018	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity
GO:0015020	glucuronosyltransferase activity
GO:0046872	metal ion binding

Biological Process

GO:0006486	protein glycosylation
GO:0015012	heparan sulfate proteoglycan biosynthetic process
GO:0050650	chondroitin sulfate proteoglycan biosynthetic process
GO:0050651	dermatan sulfate proteoglycan biosynthetic process

Cellular Component

GO:0000139	Golgi membrane
GO:0005794	Golgi apparatus
GO:0005801	cis-Golgi network
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome