InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NCAPD2

Summary

InnateDB Protein

IDBP-14176.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NCAPD2

Protein Name

non-SMC condensin I complex, subunit D2

Synonyms

CAP-D2; CNAP1; hCAP-D2;

Species

Homo sapiens

Ensembl Protein

ENSP00000325017

InnateDB Gene

IDBG-14174 (NCAPD2)

Protein Structure

UniProt Annotation

Function

Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain. {ECO:0000269PubMed:11136719}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:10958694}. Cytoplasm {ECO:0000269PubMed:10958694}. Chromosome {ECO:0000269PubMed:10958694}. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	32 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0042393	histone binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0006886	intracellular protein transport
GO:0007067	mitotic nuclear division
GO:0007076	mitotic chromosome condensation
GO:0016192	vesicle-mediated transport
GO:0030261	chromosome condensation

Cellular Component

GO:0000228	nuclear chromosome
GO:0000793	condensed chromosome
GO:0000796	condensin complex
GO:0000797	condensin core heterodimer
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0030117	membrane coat
GO:0045120	pronucleus