InnateDB Protein
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IDBP-141804.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Sip1
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Protein Name
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survival of motor neuron protein interacting protein 1
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Synonyms
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1700012N19Rik; Sip1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000021379
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InnateDB Gene
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IDBG-141802 (Sip1)
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Protein Structure
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Function |
The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus, gem {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Localized in subnuclear structures next to coiled bodies, called gems, which are highly enriched in spliceosomal snRNPs. Also found in the cytoplasm (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Experimentally validated |
Total |
5
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
22 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1913853
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InterPro |
IPR017364
Gem-associated protein 2, metazoa
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PFAM |
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PRINTS |
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PIRSF |
PIRSF038038
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9CQQ4
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PhosphoSite |
PhosphoSite-Q9CQQ4
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
66603
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UniGene |
Mm.410280
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RefSeq |
NP_079932
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MGI ID |
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MGI Symbol |
Gemin2
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OMIM |
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CCDS |
CCDS36457
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HPRD |
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IMGT |
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EMBL |
AK005928
AK007515
AK013414
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GenPept |
BAB24321
BAB25083
BAB28842
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