Mus musculus Protein: Rnf146 | |||||||||||||
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Summary | |||||||||||||
InnateDB Protein | IDBP-141895.6 | ||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
Gene Symbol | Rnf146 | ||||||||||||
Protein Name | ring finger protein 146 | ||||||||||||
Synonyms | 2610509H23Rik; Iduna; | ||||||||||||
Species | Mus musculus | ||||||||||||
Ensembl Protein | ENSMUSP00000037224 | ||||||||||||
InnateDB Gene | IDBG-141893 (Rnf146) | ||||||||||||
Protein Structure | |||||||||||||
UniProt Annotation | |||||||||||||
Function | E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation. May regulate many important biological processes, such as cell survival and DNA damage response. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent PARsylated proteins via its WWE domain and mediates their ubiquitination (By similarity). May regulate TNKS and TNKS2 subcellular location, preventing aggregation at a centrosomal location. Neuroprotective protein. Protects the brain against N- methyl-D-aspartate (NMDA) receptor-mediated glutamate excitotoxicity and ischemia, by interfering with PAR-induced cell death, called parthanatos. Prevents nuclear translocation of AIFM1 in a PAR-binding dependent manner. Does not affect PARP1 activation (By similarity). Protects against cell death induced by DNA damaging agents, such as N-methyl-N-nitro-N-nitrosoguanidine (MNNG) and rescues cells from G1 arrest. Promotes cell survival after gamma-irradiation. Facilitates DNA repair. Neuroprotective protein. Protects the brain against N-methyl-D-aspartate (NMDA) receptor-mediated glutamate excitotoxicity and ischemia, by interfering with PAR-induced cell death, called parthanatos. Prevents nuclear translocation of AIFM1 in a PAR-binding dependent manner. Does not affect PARP1 activation. {ECO:0000250, ECO:0000269PubMed:21602803, ECO:0000269PubMed:21825151}. | ||||||||||||
Subcellular Localization | Cytoplasm, cytosol {ECO:0000269PubMed:21602803}. Nucleus {ECO:0000250}. Note=Translocates to the nucleus after DNA damage, such as laser- induced DNA breaks, and concentrates at DNA breaks. This translocation requires PARP1 activation and PAR-binding (By similarity). {ECO:0000250}. | ||||||||||||
Disease Associations | |||||||||||||
Tissue Specificity | Expressed at relatively high levels in the brain. Also present in spleen, heart, kidney, testis and liver. In the brain, expressed in the cerebellum, hippocampus, striatum, cortex, frontal cortex and, at lowest levels, in olfactory bulb (at protein level). Predominantly expressed in neurons. {ECO:0000269PubMed:15813938, ECO:0000269PubMed:21602803}. | ||||||||||||
Comments | |||||||||||||
Interactions | |||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||
PDB ID | MGI:1915281 | ||||||||||||
InterPro |
IPR001841
Zinc finger, RING-type IPR004170 WWE domain IPR018123 WWE domain, subgroup |
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PFAM |
PF13639
PF14634 PF02825 |
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PRINTS | |||||||||||||
PIRSF | |||||||||||||
SMART |
SM00184
SM00678 |
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TIGRFAMs | |||||||||||||
Post-translational Modifications | |||||||||||||
Modification | |||||||||||||
Cross-References | |||||||||||||
SwissProt | Q9CZW6 | ||||||||||||
PhosphoSite | PhosphoSite-Q9CZW6 | ||||||||||||
TrEMBL | Q9CTK2 | ||||||||||||
UniProt Splice Variant | |||||||||||||
Entrez Gene | 68031 | ||||||||||||
UniGene | Mm.475694 | ||||||||||||
RefSeq | NP_001271208 | ||||||||||||
MGI ID | 2RSF | ||||||||||||
MGI Symbol | Rnf146 | ||||||||||||
OMIM | |||||||||||||
CCDS | CCDS48529 | ||||||||||||
HPRD | |||||||||||||
IMGT | |||||||||||||
EMBL | AC153912 AK003284 AK012080 AK152856 AK152907 AK169237 BC050795 | ||||||||||||
GenPept | AAH50795 BAB22689 BAB28015 BAE31549 BAE31587 BAE41005 | ||||||||||||