InnateDB Protein
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IDBP-141910.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Smarcd3
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Protein Name
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SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
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Synonyms
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1500001J14Rik; 2210409C08Rik; BAF60C;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000030791
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InnateDB Gene
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IDBG-141908 (Smarcd3)
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Protein Structure
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Function |
Plays a role in ATP dependent nucleosome remodeling by SMARCA4 containing complexes. Stimulates nuclear receptor mediated transcription (By similarity). Belongs to the neural progenitors- specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. {ECO:0000250, ECO:0000269PubMed:17640523}.
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Subcellular Localization |
Nucleus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed. {ECO:0000269PubMed:14701856}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated |
Total |
19
[view]
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Protein-Protein |
19
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
19 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1914243
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InterPro |
IPR003121
SWIB/MDM2 domain
IPR019835
SWIB domain
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PFAM |
PF02201
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PRINTS |
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PIRSF |
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SMART |
SM00151
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TIGRFAMs |
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Modification |
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SwissProt |
Q6P9Z1
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PhosphoSite |
PhosphoSite-Q6P9Z1
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
66993
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UniGene |
Mm.436539
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RefSeq |
NP_080167
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MGI ID |
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MGI Symbol |
Smarcd3
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OMIM |
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CCDS |
CCDS19126
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HPRD |
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IMGT |
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EMBL |
AK005094
AK019374
BC013122
BC060525
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GenPept |
AAH13122
AAH60525
BAB23813
BAB31685
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