Version 5.4
| Mus musculus Protein: Rspo3 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-141919.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Rspo3 | ||||||||
| Protein Name | R-spondin 3 homolog (Xenopus laevis) | ||||||||
| Synonyms | 2810459H04Rik; AW742308; Cristin1; Thsd2; | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000090287 | ||||||||
| InnateDB Gene | IDBG-141917 (Rspo3) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. {ECO:0000269PubMed:16543246, ECO:0000269PubMed:21693646}. | ||||||||
| Subcellular Localization | Secreted {ECO:0000269PubMed:16543246}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | |||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:1920030 | ||||||||
| InterPro |
IPR000884
Thrombospondin, type 1 repeat IPR006212 Furin-like repeat IPR009030 Insulin-like growth factor binding protein, N-terminal |
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| PFAM |
PF00090
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| PRINTS | |||||||||
| PIRSF | |||||||||
| SMART |
SM00209
SM00261 |
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q2TJ95 | ||||||||
| PhosphoSite | PhosphoSite-Q2TJ95 | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 72780 | ||||||||
| UniGene | Mm.45191 | ||||||||
| RefSeq | NP_082627 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Rspo3 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS23761 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AB055811 AK013366 AK076308 AY864332 BC103794 BC145929 BC145931 | ||||||||
| GenPept | AAI03795 AAI45930 AAI45932 AAX57441 BAB28811 BAC36296 BAC41353 | ||||||||