Version 5.4
Mus musculus Protein: Sf3a1
Summary
InnateDB Protein IDBP-141956.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sf3a1
Protein Name splicing factor 3a, subunit 1
Synonyms 1200014H24Rik; 5930416L09Rik; AI159724;
Species Mus musculus
Ensembl Protein ENSMUSP00000002198
InnateDB Gene IDBG-141954 (Sf3a1)
Protein Structure
UniProt Annotation
Function Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 105 interaction(s) predicted by orthology.
Experimentally validated
Total 44 [view]
Protein-Protein 44 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 105 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006396 RNA processing
GO:0006397 mRNA processing
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005684 U2-type spliceosomal complex
GO:0071013 catalytic step 2 spliceosome
Protein Structure and Domains
PDB ID MGI:1914715
InterPro IPR000061 SWAP/Surp
IPR000626 Ubiquitin-like
IPR022030 Pre-mRNA splicing factor PRP21-like protein
IPR029071 Ubiquitin-related domain
PFAM PF01805
PF00240
PF14560
PF12230
PRINTS
PIRSF
SMART SM00648
SM00213
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8K4Z5
PhosphoSite PhosphoSite-Q8K4Z5
TrEMBL
UniProt Splice Variant
Entrez Gene 67465
UniGene Mm.441789
RefSeq NP_080451
MGI ID 1WE7
MGI Symbol Sf3a1
OMIM
CCDS CCDS24380
HPRD
IMGT
EMBL AK028829 AK029095 AK030223 AL807825 BC010727 BC029753
GenPept AAH10727 AAH29753 BAC26142 BAC26294 BAC26853 CAI25745

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca