InnateDB Protein
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IDBP-14198.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ATF7IP2
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Protein Name
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activating transcription factor 7 interacting protein 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000348799
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InnateDB Gene
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IDBG-14196 (ATF7IP2)
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Protein Structure
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Function |
Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. The complex formed with MBD1 and SETDB1 represses transcription and probably couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) activity (Probable). {ECO:0000305}.
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Subcellular Localization |
Nucleus.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
5
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003961
Fibronectin, type III
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PFAM |
PF00041
PF01108
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PRINTS |
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PIRSF |
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SMART |
SM00060
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TIGRFAMs |
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Modification |
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SwissProt |
Q5U623
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PhosphoSite |
PhosphoSite-Q5U623
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TrEMBL |
H3BUP1
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UniProt Splice Variant |
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Entrez Gene |
80063
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UniGene |
Hs.742019
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RefSeq |
XP_006721016
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HUGO |
HGNC:20397
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OMIM |
613645
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CCDS |
CCDS10540
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HPRD |
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IMGT |
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EMBL |
AC022168
AC131649
AK022730
AK093414
AK223492
AK296565
AL832987
AY560615
BC033891
BC069695
BC069713
BC069730
BC137079
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GenPept |
AAH33891
AAH69695
AAH69713
AAH69730
AAI37080
AAT66299
BAB14209
BAC04157
BAD97212
BAG59185
CAH56323
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