Version 5.4
Mus musculus Protein: Tbpl2
Summary
InnateDB Protein IDBP-142045.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tbpl2
Protein Name TATA box binding protein like 2
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000079309
InnateDB Gene IDBG-142043 (Tbpl2)
Protein Structure
UniProt Annotation
Function Transcription factor required in complex with TAF3 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process. {ECO:0000269PubMed:17704303}.
Subcellular Localization Cytoplasm {ECO:0000250UniProtKB:Q6SJ96, ECO:0000269PubMed:17704303}. Nucleus {ECO:0000250UniProtKB:Q6SJ96, ECO:0000269PubMed:17704303}. Note=Present in the cytoplasm during cytokenesis. {ECO:0000250UniProtKB:Q6SJ96}.
Disease Associations
Tissue Specificity Expressed in myotubes and myofibers (at protein level). Expressed in a wide variety of tissues with highest levels in heart, lung, liver, uterus and placenta and especially the gonads. Expression is higher in the ovary than the testis, and within the ovary expression is localized to the oocytes. {ECO:0000269PubMed:14634207, ECO:0000269PubMed:15062100, ECO:0000269PubMed:16412700, ECO:0000269PubMed:17704303}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
Biological Process
GO:0006352 DNA-templated transcription, initiation
GO:0007275 multicellular organismal development
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:2684058
InterPro IPR000814 TATA-box binding protein
PFAM PF00352
PRINTS PR00686
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6SJ95
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 227606
UniGene Mm.301625
RefSeq NP_951014
MGI ID
MGI Symbol Tbpl2
OMIM
CCDS CCDS15732
HPRD
IMGT
EMBL AL844838 AY457924 BC100305 BC119160 BK005773
GenPept AAI00306 AAI19161 AAR24282 CAM19020 CAM19021 DAA06033

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca