InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Zhx2

Summary

InnateDB Protein

IDBP-142056.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zhx2

Protein Name

zinc fingers and homeoboxes 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000094164

InnateDB Gene

IDBG-142054 (Zhx2)

Protein Structure

UniProt Annotation

Function

Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00108, ECO:0000269PubMed:17056598}.

Disease Associations

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:14659886}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006402	mRNA catabolic process
GO:0035019	somatic stem cell maintenance
GO:0045665	negative regulation of neuron differentiation
GO:0045892	negative regulation of transcription, DNA-templated