InnateDB Protein
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IDBP-142071.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Actr8
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Protein Name
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ARP8 actin-related protein 8 homolog (S. cerevisiae)
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Synonyms
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5730542K05Rik; ARP8;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000016115
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InnateDB Gene
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IDBG-142069 (Actr8)
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Protein Structure
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Function |
Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize (By similarity). {ECO:0000250}.Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Chromosome {ECO:0000250}. Note=Specifically localizes to mitotic chromosomes. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
19 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1860775
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InterPro |
IPR004000
Actin-related protein
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PFAM |
PF00022
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PRINTS |
PR00190
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PIRSF |
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SMART |
SM00268
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TIGRFAMs |
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Modification |
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SwissProt |
Q8R2S9
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PhosphoSite |
PhosphoSite-Q8R2S9
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
56249
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UniGene |
Mm.403632
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RefSeq |
NP_081769
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MGI ID |
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MGI Symbol |
Actr8
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OMIM |
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CCDS |
CCDS26891
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HPRD |
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IMGT |
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EMBL |
AK017815
BC027281
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GenPept |
AAH27281
BAB30952
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