InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Il1f8

Summary

InnateDB Protein

IDBP-142098.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Il1f8

Protein Name

interleukin 1 family, member 8

Synonyms

2310043N20Rik; Il36b;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028363

InnateDB Gene

IDBG-142096 (Il1f8)

Protein Structure

UniProt Annotation

Function

Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensin 4 and beta-defensin 103 as well as a number of matrix metalloproteases (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005149	interleukin-1 receptor binding

Biological Process

GO:0001819	positive regulation of cytokine production
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0032755	positive regulation of interleukin-6 production
GO:0045582	positive regulation of T cell differentiation