InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cldn5

Summary

InnateDB Protein

IDBP-142209.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cldn5

Protein Name

claudin 5

Synonyms

AI854493; MBEC1; Tmvcf;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000041925

InnateDB Gene

IDBG-142207 (Cldn5)

Protein Structure

UniProt Annotation

Function

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. {ECO:0000250}.

Subcellular Localization

Cell junction, tight junction {ECO:0000269PubMed:9892664}. Cell membrane {ECO:0000269PubMed:9892664}; Multi-pass membrane protein {ECO:0000269PubMed:9892664}.

Disease Associations

Tissue Specificity

Widely expressed with highest levels in the lung. {ECO:0000269PubMed:9892664}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	1 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0016337	single organismal cell-cell adhesion
GO:0016338	calcium-independent cell-cell adhesion
GO:0042552	myelination

Cellular Component

GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005923	tight junction
GO:0016021	integral component of membrane
GO:0033270	paranode region of axon
GO:0043220	Schmidt-Lanterman incisure
GO:0070062	extracellular vesicular exosome