InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Foxc1

Summary

InnateDB Protein

IDBP-142258.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Foxc1

Protein Name

forkhead box C1

Synonyms

ch; fkh-1; Fkh1; FREAC3; frkhda; Mf1; Mf4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000052196

InnateDB Gene

IDBG-142256 (Foxc1)

Protein Structure

UniProt Annotation

Function

Transcriptional regulator. Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Expressed in many embryonic tissues, including prechondrogenic mesenchyme, periocular mesenchyme, meninges, endothelial cells, and kidney. Detected in adult brain, heart, kidney, adrenal gland, lung and testis, with lower levels in stomach, spleen and thymus. {ECO:0000269PubMed:9767123}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008301	DNA binding, bending
GO:0031490	chromatin DNA binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001501	skeletal system development
GO:0001503	ossification
GO:0001541	ovarian follicle development
GO:0001568	blood vessel development
GO:0001654	eye development
GO:0001657	ureteric bud development
GO:0001701	in utero embryonic development
GO:0001756	somitogenesis
GO:0001822	kidney development
GO:0001945	lymph vessel development
GO:0001974	blood vessel remodeling
GO:0003007	heart morphogenesis
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007219	Notch signaling pathway
GO:0007420	brain development
GO:0007507	heart development
GO:0008354	germ cell migration
GO:0014032	neural crest cell development
GO:0030199	collagen fibril organization
GO:0030203	glycosaminoglycan metabolic process
GO:0032808	lacrimal gland development
GO:0035050	embryonic heart tube development
GO:0042475	odontogenesis of dentin-containing tooth
GO:0043010	camera-type eye development
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045930	negative regulation of mitotic cell cycle
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046620	regulation of organ growth
GO:0048010	vascular endothelial growth factor receptor signaling pathway
GO:0048341	paraxial mesoderm formation
GO:0048762	mesenchymal cell differentiation
GO:0048844	artery morphogenesis
GO:0050880	regulation of blood vessel size
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity
GO:0055010	ventricular cardiac muscle tissue morphogenesis
GO:0060038	cardiac muscle cell proliferation
GO:1902257	negative regulation of apoptotic process involved in outflow tract morphogenesis