Version 5.4
Mus musculus Protein: Gmds
Summary
InnateDB Protein IDBP-142289.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gmds
Protein Name GDP-mannose 4, 6-dehydratase
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000036696
InnateDB Gene IDBG-142287 (Gmds)
Protein Structure
UniProt Annotation
Function Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose. {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0008446 GDP-mannose 4,6-dehydratase activity
GO:0008831 dTDP-4-dehydrorhamnose reductase activity
GO:0050662 coenzyme binding
GO:0070401 NADP+ binding
Biological Process
GO:0007219 Notch signaling pathway
GO:0019673 GDP-mannose metabolic process
GO:0042351 'de novo' GDP-L-fucose biosynthetic process
GO:0044237 cellular metabolic process
GO:0045226 extracellular polysaccharide biosynthetic process
Cellular Component
GO:0005575 cellular_component
GO:0005622 intracellular
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1891112
InterPro IPR001509 NAD-dependent epimerase/dehydratase
IPR005913 dTDP-4-dehydrorhamnose reductase
IPR006368 GDP-mannose 4,6-dehydratase
PFAM PF01370
PF04321
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8K0C9
PhosphoSite PhosphoSite-Q8K0C9
TrEMBL
UniProt Splice Variant
Entrez Gene 218138
UniGene Mm.247143
RefSeq NP_666153
MGI ID
MGI Symbol Gmds
OMIM
CCDS CCDS26426
HPRD
IMGT
EMBL AL645643 AL645664 AL645697 AL645763 AL645783 BC031788 BC093502
GenPept AAH31788 AAH93502 CAI24125 CAI24766 CAI24852 CAI25621 CAI25768

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca