InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Wrnip1

Summary

InnateDB Protein

IDBP-142429.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Wrnip1

Protein Name

Werner helicase interacting protein 1

Synonyms

4833444L21Rik; WHIP; Wrnip;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021832

InnateDB Gene

IDBG-142427 (Wrnip1)

Protein Structure

UniProt Annotation

Function

Functions as a modulator for initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. Has an intrinsic ATPase activity that functions as a sensor of DNA damage or of arrested replication forks and regulates the extent of DNA synthesis (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:11301316}. Note=Colocalizes with WRN in granular structures in the nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0009378	four-way junction helicase activity
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0042802	identical protein binding

Biological Process

GO:0000731	DNA synthesis involved in DNA repair
GO:0006200	ATP catabolic process
GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0030174	regulation of DNA-dependent DNA replication initiation

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0016020	membrane
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:1926153

InterPro

IPR002611 IstB-like ATP-binding protein
IPR003593 AAA+ ATPase domain
IPR003959 ATPase, AAA-type, core
IPR006642 Zinc finger, Rad18-type putative
IPR008533 Domain of unknown function DUF815
IPR008824 DNA helicase, Holliday junction RuvB type, N-terminal
IPR011704 ATPase, dynein-related, AAA domain
IPR021886 MgsA AAA+ ATPase C-terminal
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM