Version 5.4
Mus musculus Protein: Psd4
Summary
InnateDB Protein IDBP-142438.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Psd4
Protein Name pleckstrin and Sec7 domain containing 4
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000062415
InnateDB Gene IDBG-142430 (Psd4)
Protein Structure
UniProt Annotation
Function Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5- bisphosphate and phosphatidylinositol 4,5-bisphosphate (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}. Note=Accumulates in dynamic actin-rich membrane ruffles and microvilli-like structures. Recruited to membranes via phosphatidylinositol phosphate-binding (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005086 ARF guanyl-nucleotide exchange factor activity
GO:0008289 lipid binding
Biological Process
GO:0030182 neuron differentiation
GO:0032012 regulation of ARF protein signal transduction
GO:0043087 regulation of GTPase activity
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030054 cell junction
Protein Structure and Domains
PDB ID MGI:2674093
InterPro IPR000904 Sec7 domain
IPR001849 Pleckstrin homology domain
PFAM PF01369
PF00169
PRINTS
PIRSF
SMART SM00222
SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BLR5
PhosphoSite PhosphoSite-Q8BLR5
TrEMBL
UniProt Splice Variant
Entrez Gene 215632
UniGene Mm.490434
RefSeq NP_808279
MGI ID
MGI Symbol Psd4
OMIM
CCDS CCDS15737
HPRD
IMGT
EMBL AK043669 AK148489 AK150238 AK163628 AK169859 AL732528 BC046518 BC068231
GenPept AAH46518 AAH68231 BAC31612 BAE28582 BAE29402 BAE37428 BAE41415 CAM17807

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca