InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ido1

Summary

InnateDB Protein

IDBP-142450.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ido1

Protein Name

indoleamine 2,3-dioxygenase 1

Synonyms

Ido; Indo;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033956

InnateDB Gene

IDBG-142448 (Ido1)

Protein Structure

UniProt Annotation

Function

Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen. {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Detected in the apical cells of the caput epididymis and in the kidney blood vessels (at protein level). {ECO:0000269PubMed:17499941}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	7 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004833	tryptophan 2,3-dioxygenase activity
GO:0005515	protein binding
GO:0020037	heme binding
GO:0033754	indoleamine 2,3-dioxygenase activity
GO:0046872	metal ion binding

Biological Process

GO:0002534	cytokine production involved in inflammatory response
GO:0002666	positive regulation of T cell tolerance induction
GO:0002678	positive regulation of chronic inflammatory response
GO:0002830	positive regulation of type 2 immune response
GO:0006952	defense response
GO:0006954	inflammatory response
GO:0019441	tryptophan catabolic process to kynurenine
GO:0032496	response to lipopolysaccharide
GO:0032693	negative regulation of interleukin-10 production
GO:0032735	positive regulation of interleukin-12 production
GO:0033555	multicellular organismal response to stress
GO:0034276	kynurenic acid biosynthetic process
GO:0036269	swimming behavior
GO:0042130	negative regulation of T cell proliferation
GO:0043065	positive regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0046007	negative regulation of activated T cell proliferation
GO:0055114	oxidation-reduction process
GO:0070233	negative regulation of T cell apoptotic process