Version 5.4
Mus musculus Protein: Ocrl
Summary
InnateDB Protein IDBP-142453.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Ocrl
Protein Name oculocerebrorenal syndrome of Lowe
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000001202
InnateDB Gene IDBG-142451 (Ocrl)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO:0005515 protein binding
GO:0030675 Rac GTPase activator activity
GO:0048365 Rac GTPase binding
Biological Process
GO:0001701 in utero embryonic development
GO:0007165 signal transduction
GO:0032314 regulation of Rac GTPase activity
GO:0032855 positive regulation of Rac GTPase activity
GO:0042384 cilium assembly
GO:0046856 phosphatidylinositol dephosphorylation
Cellular Component
GO:0001750 photoreceptor outer segment
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0005905 coated pit
GO:0030136 clathrin-coated vesicle
GO:0030670 phagocytic vesicle membrane
GO:0031901 early endosome membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:109589
InterPro IPR000198 Rho GTPase-activating protein domain
IPR000300 Inositol polyphosphate-related phosphatase
IPR005135 Endonuclease/exonuclease/phosphatase
IPR008936 Rho GTPase activation protein
PFAM PF00620
PF03372
PF14529
PRINTS
PIRSF
SMART SM00324
SM00128
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6NVF0
PhosphoSite PhosphoSite-Q6NVF0
TrEMBL Q80XM6
UniProt Splice Variant
Entrez Gene 320634
UniGene Mm.472553
RefSeq NP_796189
MGI ID
MGI Symbol Ocrl
OMIM
CCDS CCDS40957
HPRD
IMGT
EMBL AK041963 AK047906 AL714010 BC043709 BC054840 BC068146
GenPept AAH43709 AAH54840 AAH68146 BAC33188 BAE20614 CAM24771 CAM24772

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca