InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rgl3

Summary

InnateDB Protein

IDBP-142468.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rgl3

Protein Name

ral guanine nucleotide dissociation stimulator-like 3

Synonyms

1300003D20Rik; mFLJ00153;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000035726

InnateDB Gene

IDBG-142466 (Rgl3)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide exchange factor (GEF) for Ral-A. Potential effector of GTPase HRas and Ras-related protein M-Ras. Negatively regulates Elk-1-dependent gene induction downstream of HRas and MEKK1. {ECO:0000269PubMed:10869344, ECO:0000269PubMed:11313946}.

Subcellular Localization

Disease Associations

Tissue Specificity

Widely expressed. Expressed at high levels in the liver and kidney. {ECO:0000269PubMed:10869344, ECO:0000269PubMed:11313946}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0008321	Ral guanyl-nucleotide exchange factor activity
GO:0017016	Ras GTPase binding

Biological Process

GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0032315	regulation of Ral GTPase activity
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622

intracellular

Protein Structure and Domains

PDB ID

MGI:1918996

InterPro

IPR000159 Ras-association
IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
IPR001895 Guanine-nucleotide dissociation stimulator CDC25
IPR023578 Ras guanine nucleotide exchange factor, domain
IPR029071 Ubiquitin-related domain

PFAM

PF00788
PF00618
PF00617

PRINTS

PIRSF

SMART

SM00314
SM00229
SM00147

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3UYI5