Version 5.4
Mus musculus Protein: Kctd16
Summary
InnateDB Protein IDBP-142476.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Kctd16
Protein Name potassium channel tetramerisation domain containing 16
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000089547
InnateDB Gene IDBG-142474 (Kctd16)
Protein Structure
UniProt Annotation
Function Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization. {ECO:0000269PubMed:20400944}.
Subcellular Localization Cell junction, synapse, presynaptic cell membrane {ECO:0000269PubMed:20400944}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000269PubMed:20400944}. Note=Colocalizes with GABRB1.
Disease Associations
Tissue Specificity Expressed in the brain, mainly in the hippocampus. {ECO:0000269PubMed:20400944}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0051260 protein homooligomerization
Cellular Component
GO:0030054 cell junction
GO:0042734 presynaptic membrane
GO:0043235 receptor complex
GO:0045211 postsynaptic membrane
Protein Structure and Domains
PDB ID MGI:1914659
InterPro IPR000210 BTB/POZ-like
IPR003131 Potassium channel tetramerisation-type BTB domain
IPR011333 BTB/POZ fold
PFAM PF02214
PRINTS
PIRSF
SMART SM00225
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5DTY9
PhosphoSite PhosphoSite-Q5DTY9
TrEMBL
UniProt Splice Variant
Entrez Gene 383348
UniGene
RefSeq NP_080411
MGI ID
MGI Symbol Kctd16
OMIM
CCDS CCDS50264
HPRD
IMGT
EMBL AC098707 AC127249 AK005863 AK220381
GenPept BAB24283 BAD90438

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca