InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hey2

Summary

InnateDB Protein

IDBP-142502.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hey2

Protein Name

hairy/enhancer-of-split related with YRPW motif 2

Synonyms

bHLHb32; CHF1; Herp1; hesr2; Hrt2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000019924

InnateDB Gene

IDBG-142500 (Hey2)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor which functions as a downstream effector of Notch signaling in cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY1 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3. {ECO:0000269PubMed:10692439, ECO:0000269PubMed:11095750, ECO:0000269PubMed:11160397, ECO:0000269PubMed:11486045, ECO:0000269PubMed:12372253, ECO:0000269PubMed:12372254, ECO:0000269PubMed:12454287, ECO:0000269PubMed:12947105, ECO:0000269PubMed:15107403, ECO:0000269PubMed:15297376, ECO:0000269PubMed:15345511, ECO:0000269PubMed:15485867, ECO:0000269PubMed:15680351, ECO:0000269PubMed:16199874, ECO:0000269PubMed:17259303, ECO:0000269PubMed:17303760, ECO:0000269PubMed:17332425}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00380, ECO:0000255PROSITE-ProRule:PRU00981, ECO:0000269PubMed:11741889}.

Disease Associations

Tissue Specificity

Highly expressed in the aorta, lower expression detected in the heart, brain, kidney, lung, muscle, ovary and testis. {ECO:0000269PubMed:10588864, ECO:0000269PubMed:10692439, ECO:0000269PubMed:10860664, ECO:0000269PubMed:12947105}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000983	RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity
GO:0000988	protein binding transcription factor activity
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0035939	microsatellite binding
GO:0042826	histone deacetylase binding
GO:0043565	sequence-specific DNA binding
GO:0046983	protein dimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001568	blood vessel development
GO:0001570	vasculogenesis
GO:0003150	muscular septum morphogenesis
GO:0003151	outflow tract morphogenesis
GO:0003171	atrioventricular valve development
GO:0003184	pulmonary valve morphogenesis
GO:0003186	tricuspid valve morphogenesis
GO:0003195	tricuspid valve formation
GO:0003199	endocardial cushion to mesenchymal transition involved in heart valve formation
GO:0003208	cardiac ventricle morphogenesis
GO:0003214	cardiac left ventricle morphogenesis
GO:0003215	cardiac right ventricle morphogenesis
GO:0003222	ventricular trabecula myocardium morphogenesis
GO:0003300	cardiac muscle hypertrophy
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007219	Notch signaling pathway
GO:0007389	pattern specification process
GO:0007507	heart development
GO:0009948	anterior/posterior axis specification
GO:0010460	positive regulation of heart rate
GO:0010468	regulation of gene expression
GO:0010629	negative regulation of gene expression
GO:0010667	negative regulation of cardiac muscle cell apoptotic process
GO:0014031	mesenchymal cell development
GO:0014898	cardiac muscle hypertrophy in response to stress
GO:0035910	ascending aorta morphogenesis
GO:0035912	dorsal aorta morphogenesis
GO:0036304	umbilical cord morphogenesis
GO:0045165	cell fate commitment
GO:0045607	regulation of auditory receptor cell differentiation
GO:0045746	negative regulation of Notch signaling pathway
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0055015	ventricular cardiac muscle cell development
GO:0060045	positive regulation of cardiac muscle cell proliferation
GO:0060317	cardiac epithelial to mesenchymal transition
GO:0060347	heart trabecula formation
GO:0060411	cardiac septum morphogenesis
GO:0060412	ventricular septum morphogenesis
GO:0060413	atrial septum morphogenesis
GO:0060633	negative regulation of transcription initiation from RNA polymerase II promoter
GO:0060716	labyrinthine layer blood vessel development
GO:0060840	artery development
GO:0060842	arterial endothelial cell differentiation
GO:0060948	cardiac vascular smooth muscle cell development
GO:0060977	coronary vasculature morphogenesis
GO:0061156	pulmonary artery morphogenesis
GO:0061314	Notch signaling involved in heart development
GO:0065004	protein-DNA complex assembly
GO:0090102	cochlea development
GO:0097084	vascular smooth muscle cell development
GO:2000678	negative regulation of transcription regulatory region DNA binding
GO:2000820	negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation
GO:2001212	regulation of vasculogenesis

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0016580	Sin3 complex
GO:0017053	transcriptional repressor complex