InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Asrgl1

Summary

InnateDB Protein

IDBP-142505.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Asrgl1

Protein Name

asparaginase like 1

Synonyms

2410004D18Rik; ALP; ALP1; AU040643; AW060375;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000051709

InnateDB Gene

IDBG-142503 (Asrgl1)

Protein Structure

UniProt Annotation

Function

Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L- Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Note=Midpiece of sperm tail. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003948	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity
GO:0004067	asparaginase activity
GO:0008798	beta-aspartyl-peptidase activity
GO:0016787	hydrolase activity