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InnateDB Protein
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IDBP-142546.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Serpinb1a
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Protein Name
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serine (or cysteine) peptidase inhibitor, clade B, member 1a
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Synonyms
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1190005M04Rik; AI325983; EI; EIA; ELANH2; LEI; M/NEI; MNEI; PI2;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000089257
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InnateDB Gene
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IDBG-142542 (Serpinb1a)
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Protein Structure
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| Function |
Regulates the activity of the neutrophil proteases and thus, forms complexes with chymotrypsin, elastase, cathepsin G and proteinase-3. {ECO:0000269PubMed:12189154}.
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| Subcellular Localization |
Cytoplasm {ECO:0000250}.
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| Disease Associations |
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| Tissue Specificity |
Ubiquitous with higher expression in pancreas, spleen and bone marrow. {ECO:0000269PubMed:11863365, ECO:0000269PubMed:12189154}.
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
| Experimentally validated |
| Total |
9
[view]
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| Protein-Protein |
9
[view]
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| Protein-DNA |
0
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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| Predicted by orthology |
| Total |
5 [view]
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Molecular Function |
| Accession |
GO Term |
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GO:0004867
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serine-type endopeptidase inhibitor activity
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| Biological Process |
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GO:0010951
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negative regulation of endopeptidase activity
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| Cellular Component |
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| PDB ID |
MGI:1913472
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| InterPro |
IPR023796
Serpin domain
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| PFAM |
PF00079
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| PRINTS |
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| PIRSF |
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| SMART |
SM00093
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| TIGRFAMs |
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| Modification |
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| SwissProt |
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| PhosphoSite |
PhosphoSite-Q9D154
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| TrEMBL |
Z4YK03
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| UniProt Splice Variant |
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| Entrez Gene |
66222
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| UniGene |
Mm.20144
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| RefSeq |
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| MGI ID |
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| MGI Symbol |
Serpinb1a
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| OMIM |
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| CCDS |
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| HPRD |
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| IMGT |
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| EMBL |
AL645808
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| GenPept |
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Version 5.4