InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pax8

Summary

InnateDB Protein

IDBP-142558.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pax8

Protein Name

paired box gene 8

Synonyms

Pax-8;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028355

InnateDB Gene

IDBG-142554 (Pax8)

Protein Structure

UniProt Annotation

Function

Thought to encode a transcription factor. It may have a role in kidney cell differentiation. May play a regulatory role in mammalian development.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Expressed in the developing excretory system and the thyroid gland.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0001655	urogenital system development
GO:0001656	metanephros development
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0001822	kidney development
GO:0001823	mesonephros development
GO:0003337	mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007417	central nervous system development
GO:0009887	organ morphogenesis
GO:0030154	cell differentiation
GO:0030878	thyroid gland development
GO:0039003	pronephric field specification
GO:0042472	inner ear morphogenesis
GO:0042981	regulation of apoptotic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048793	pronephros development
GO:0071371	cellular response to gonadotropin stimulus
GO:0071599	otic vesicle development
GO:0072050	S-shaped body morphogenesis
GO:0072073	kidney epithelium development
GO:0072108	positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0072164	mesonephric tubule development
GO:0072207	metanephric epithelium development
GO:0072221	metanephric distal convoluted tubule development
GO:0072278	metanephric comma-shaped body morphogenesis
GO:0072284	metanephric S-shaped body morphogenesis
GO:0072289	metanephric nephron tubule formation
GO:0072305	negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis
GO:0072307	regulation of metanephric nephron tubule epithelial cell differentiation
GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis
GO:1900212	negative regulation of mesenchymal cell apoptotic process involved in metanephros development
GO:1900215	negative regulation of apoptotic process involved in metanephric collecting duct development
GO:1900218	negative regulation of apoptotic process involved in metanephric nephron tubule development
GO:2000594	positive regulation of metanephric DCT cell differentiation
GO:2000611	positive regulation of thyroid hormone generation
GO:2000612	regulation of thyroid-stimulating hormone secretion