InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Elf2

Summary

InnateDB Protein

IDBP-142716.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Elf2

Protein Name

E74-like factor 2

Synonyms

2610036A20Rik; A230104O07Rik; AW111824; BB183398; EU32; NERF; NERF-1A; NERF-1B; NERF-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000061076

InnateDB Gene

IDBG-142712 (Elf2)

Protein Structure

UniProt Annotation

Function

Probably transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter. {ECO:0000250}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Expressed in all tissues examined. Highest levels in thymocytes and bone marrow. {ECO:0000269PubMed:9001422}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0030154	cell differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated