InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Reck

Summary

InnateDB Protein

IDBP-142822.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Reck

Protein Name

reversion-inducing-cysteine-rich protein with kazal motifs

Synonyms

mRECK; St15;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030198

InnateDB Gene

IDBG-142820 (Reck)

Protein Structure

UniProt Annotation

Function

Negatively regulates matrix metalloproteinase-9 (MMP-9) by suppressing MMP-9 secretion and by direct inhibition of its enzymatic activity. RECK down-regulation by oncogenic signals may facilitate tumor invasion and metastasis. Appears to also regulate MMP-2 and MT1-MMP, which are involved in cancer progression (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane; Lipid-anchor, GPI-anchor.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004866	endopeptidase inhibitor activity
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005515	protein binding
GO:0030414	peptidase inhibitor activity

Biological Process

GO:0001955	blood vessel maturation
GO:0007566	embryo implantation
GO:0010951	negative regulation of endopeptidase activity
GO:0030198	extracellular matrix organization