Version 5.4
Mus musculus Protein: Wdyhv1
Summary
InnateDB Protein IDBP-142875.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Wdyhv1
Protein Name WDYHV motif containing 1
Synonyms 2410187C16Rik; AU014961; AW550036; Ntaq1;
Species Mus musculus
Ensembl Protein ENSMUSP00000064622
InnateDB Gene IDBG-142871 (Wdyhv1)
Protein Structure
UniProt Annotation
Function Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N- terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C- terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine. {ECO:0000269PubMed:19560421}.
Subcellular Localization Cytoplasm, cytosol {ECO:0000269PubMed:19560421}. Nucleus {ECO:0000269PubMed:19560421}.
Disease Associations
Tissue Specificity Widely expressed. {ECO:0000269PubMed:19560421}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO:0070773 protein-N-terminal glutamine amidohydrolase activity
Biological Process
GO:0006464 cellular protein modification process
GO:0030163 protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
Protein Structure and Domains
PDB ID MGI:1924023
InterPro IPR023128 Protein N-terminal glutamine amidohydrolase, alpha beta roll
PFAM PF09764
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q80WB5
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 76773
UniGene
RefSeq NP_084010
MGI ID
MGI Symbol Wdyhv1
OMIM
CCDS CCDS27490
HPRD
IMGT
EMBL AK150578 BC051524
GenPept AAH51524 BAE29673

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca