InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rab33b

Summary

InnateDB Protein

IDBP-143138.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rab33b

Protein Name

RAB33B, member of RAS oncogene family

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000063054

InnateDB Gene

IDBG-143136 (Rab33b)

Protein Structure

UniProt Annotation

Function

Protein transport. Acts, in coordination with RAB6A, to regulate intra-Golgi retrograde trafficking (By similarity). It is involved in autophagy, acting as a modulator of autophagosome formation. {ECO:0000250, ECO:0000269PubMed:18448665}.

Subcellular Localization

Golgi apparatus membrane; Lipid-anchor. Golgi apparatus, cis-Golgi network. Note=Under starvation conditions punctate RAB33B-positive structures are often observed in the cytoplasm.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:9512502}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0006913	nucleocytoplasmic transport
GO:0006914	autophagy
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:2000156	regulation of retrograde vesicle-mediated transport, Golgi to ER
GO:2000785	regulation of autophagic vacuole assembly

Cellular Component

GO:0000139	Golgi membrane
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005796	Golgi lumen
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1330805

InterPro

IPR000795 Elongation factor, GTP-binding domain
IPR001806 Small GTPase superfamily
IPR002041 Ran GTPase
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR006762 Gtr1/RagA G protein
IPR013684 Mitochondrial Rho-like
IPR019009 Signal recognition particle receptor, beta subunit
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00009
PF00071
PF00025
PF04670
PF08477
PF09439

PRINTS

PR00315
PR00449
PR00627
PR00328

PIRSF

SMART

SM00176
SM00174
SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt