InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Setd7

Summary

InnateDB Protein

IDBP-143163.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Setd7

Protein Name

SET domain containing (lysine methyltransferase) 7

Synonyms

1600028F23Rik; H3K4MT; KMT7; mKIAA1717; Set7; Set7/9;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000043492

InnateDB Gene

IDBG-143161 (Setd7)

Protein Structure

UniProt Annotation

Function

Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. {ECO:0000269PubMed:12711597}.

Subcellular Localization

Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0005515	protein binding
GO:0016279	protein-lysine N-methyltransferase activity
GO:0018024	histone-lysine N-methyltransferase activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0018026	peptidyl-lysine monomethylation
GO:0018027	peptidyl-lysine dimethylation
GO:0034968	histone lysine methylation