InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nobox

Summary

InnateDB Protein

IDBP-143198.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nobox

Protein Name

NOBOX oogenesis homeobox

Synonyms

OG2; Og2x;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031749

InnateDB Gene

IDBG-143196 (Nobox)

Protein Structure

UniProt Annotation

Function

Transcription factor which plays an essential role in postnatal follicle development. Binds preferentially to the DNA sequences 5'-TAATTG-3', 5'-TAGTTG-3' and 5'-TAATTA-3'. Directly regulates the transcription of POU5F1 and GDF9 during early folliculogenesis. {ECO:0000269PubMed:15326356, ECO:0000269PubMed:16997917}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Specifically expressed in ovaries and testes. In ovaries, expressed in oocytes from primordial through antral follicles but not in granulosa cells, theca cells and corpora lutea. {ECO:0000269PubMed:11804785}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001541	ovarian follicle development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048477	oogenesis