InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fads2

Summary

InnateDB Protein

IDBP-143304.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fads2

Protein Name

fatty acid desaturase 2

Synonyms

2900042M13Rik; Fadsd2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025567

InnateDB Gene

IDBG-143302 (Fads2)

Protein Structure

UniProt Annotation

Function

Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma- linoleic acid (GLA) (18:3n-6) and stearidonic acid (18:4n-3) respectively and other desaturation steps. Highly unsaturated fatty acids (HUFA) play pivotal roles in many biological functions (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Highly expressed in the adrenal gland, liver, brain, and testis, tissues where lipogenesis and steroidogenesis are active. Also detected in lung, heart, and skeletal muscle. {ECO:0000269PubMed:11792729, ECO:0000269PubMed:9867867}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004768	stearoyl-CoA 9-desaturase activity
GO:0005506	iron ion binding
GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
GO:0020037	heme binding

Biological Process

GO:0006629	lipid metabolic process
GO:0006633	fatty acid biosynthetic process
GO:0006636	unsaturated fatty acid biosynthetic process
GO:0055114	oxidation-reduction process