InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Zscan10

Summary

InnateDB Protein

IDBP-143330.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zscan10

Protein Name

zinc finger and SCAN domain containing 10

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000093255

InnateDB Gene

IDBG-143328 (Zscan10)

Protein Structure

UniProt Annotation

Function

Embryonic stem (ES) cell-specific transcription factor required to maintain ES cell pluripotency. Can both activate and /or repress expression of target genes, depending on the context. Specifically binds the 5'-[GA]CGCNNGCG[CT]-3' DNA consensus sequence. Regulates expression of POU5F1/OCT4, ZSCAN4 and ALYREF/THOC4. {ECO:0000269PubMed:16971461, ECO:0000269PubMed:17628018, ECO:0000269PubMed:19740739}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00187, ECO:0000269PubMed:16971461, ECO:0000269PubMed:17628018}.

Disease Associations

Tissue Specificity

Embryonic stem (ES) cell-specific. Not expressed in adult, except in testis. {ECO:0000269PubMed:16971461, ECO:0000269PubMed:17628018}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0045892	negative regulation of transcription, DNA-templated
GO:0048863	stem cell differentiation