InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Klhl6

Summary

InnateDB Protein

IDBP-143336.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Klhl6

Protein Name

kelch-like 6 (Drosophila)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000053023

InnateDB Gene

IDBG-143334 (Klhl6)

Protein Structure

UniProt Annotation

Function

Involved in B-lymphocyte antigen receptor signaling and germinal center formation. {ECO:0000269PubMed:16166635}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed in embryonic blood vessel endothelial cells but not in the vasculature of adult organs. In adults, detected at high levels in hematopoietic and lymphoid organs. {ECO:0000269PubMed:16166635}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0002467	germinal center formation
GO:0050853	B cell receptor signaling pathway

Cellular Component

GO:0005575

cellular_component

Protein Structure and Domains

PDB ID

MGI:2686922

InterPro

IPR000210 BTB/POZ-like
IPR006652 Kelch repeat type 1
IPR011333 BTB/POZ fold
IPR011498 Kelch repeat type 2
IPR011705 BTB/Kelch-associated
IPR013069 BTB/POZ
IPR017096 Kelch-like protein, gigaxonin type

PFAM

PF01344
PF07646
PF07707
PF00651

PRINTS

PIRSF

PIRSF037037

SMART

SM00225
SM00612
SM00875

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt