InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Acp5

Summary

InnateDB Protein

IDBP-143416.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Acp5

Protein Name

acid phosphatase 5, tartrate resistant

Synonyms

TRACP; TRAP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000065425

InnateDB Gene

IDBG-143414 (Acp5)

Protein Structure

UniProt Annotation

Function

May play a role in the process of bone resorption. The osteoclastic trap acts on nucleotide tri- and diphosphates with higher affinity, compared with other substrates.

Subcellular Localization

Lysosome.

Disease Associations

Tissue Specificity

Characteristic constituent of osteoclasts.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003993	acid phosphatase activity
GO:0008198	ferrous iron binding
GO:0008199	ferric iron binding
GO:0016787	hydrolase activity

Biological Process

GO:0016311	dephosphorylation
GO:0032496	response to lipopolysaccharide
GO:0032691	negative regulation of interleukin-1 beta production
GO:0032695	negative regulation of interleukin-12 production
GO:0032720	negative regulation of tumor necrosis factor production
GO:0032929	negative regulation of superoxide anion generation
GO:0034097	response to cytokine
GO:0045019	negative regulation of nitric oxide biosynthetic process
GO:0045453	bone resorption
GO:0050728	negative regulation of inflammatory response
GO:0050830	defense response to Gram-positive bacterium
GO:0060349	bone morphogenesis