Version 5.4
Mus musculus Protein: Prss40
Summary
InnateDB Protein IDBP-143433.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Prss40
Protein Name protease, serine, 40
Synonyms Tesp2;
Species Mus musculus
Ensembl Protein ENSMUSP00000045118
InnateDB Gene IDBG-143431 (Prss40)
Protein Structure
UniProt Annotation
Function May play an important role in the sperm/egg interaction; released during the acrosome reaction. {ECO:0000269PubMed:9588171}.
Subcellular Localization Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269PubMed:9588171}. Secreted {ECO:0000269PubMed:9588171}.
Disease Associations
Tissue Specificity Expressed in testis. More specifically, abundantly expressed in the haploid round spermatid. {ECO:0000269PubMed:9588171}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0001669 acrosomal vesicle
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID MGI:1270857
InterPro IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR015420 Peptidase S1A, nudel
PFAM PF00089
PF09342
PRINTS PR00722
PIRSF
SMART SM00020
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A6H6T1
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 21756
UniGene Mm.14418
RefSeq NP_033382
MGI ID
MGI Symbol Prss40
OMIM
CCDS CCDS14870
HPRD
IMGT
EMBL AB008911 AC106841 BC145989
GenPept AAI45990 BAA26133

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca