InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pax5

Summary

InnateDB Protein

IDBP-143473.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pax5

Protein Name

paired box gene 5

Synonyms

BSAP; EBB-1; KLP; Pax-5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000014174

InnateDB Gene

IDBG-143469 (Pax5)

Protein Structure

UniProt Annotation

Function

May play an important role in B-cell differentiation as well as neural development and spermatogenesis. Involved in the regulation of the CD19 gene, a B-lymphoid-specific target gene.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	14 [view]
Protein-DNA	12 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007283	spermatogenesis
GO:0007399	nervous system development
GO:0009887	organ morphogenesis
GO:0035914	skeletal muscle cell differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051573	negative regulation of histone H3-K9 methylation