InnateDB Protein
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IDBP-143537.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Elf4
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Protein Name
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E74-like factor 4 (ets domain transcription factor)
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Synonyms
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AV314029; BC042423; ENSMUSG00000053512; Gm9907; Mef;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000033429
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InnateDB Gene
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IDBG-143535 (Elf4)
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Protein Structure
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Function |
Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of LYZ. Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity). Also transactivates the PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2. Controls cell senescence in a p53-dependent manner. Can also promote cellular transformation through inhibition of the p16 pathway. {ECO:0000250, ECO:0000269PubMed:12387738, ECO:0000269PubMed:19380490, ECO:0000269PubMed:19412182}.
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Subcellular Localization |
Nucleus, PML body {ECO:0000250}. Note=Accumulation into PML nuclear bodies is mediated by PML. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
9 [view]
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Molecular Function |
Accession |
GO Term |
GO:0000981
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sequence-specific DNA binding RNA polymerase II transcription factor activity
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GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0043565
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sequence-specific DNA binding
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Biological Process |
GO:0001787
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natural killer cell proliferation
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GO:0001866
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NK T cell proliferation
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0006366
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transcription from RNA polymerase II promoter
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GO:0030154
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cell differentiation
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GO:0045893
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positive regulation of transcription, DNA-templated
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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Cellular Component |
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PDB ID |
MGI:1928377
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InterPro |
IPR000418
Ets domain
IPR022084
Transcription factor Elf, N-terminal
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PFAM |
PF00178
PF12310
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PRINTS |
PR00454
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PIRSF |
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SMART |
SM00413
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Z2U4
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PhosphoSite |
PhosphoSite-Q9Z2U4
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TrEMBL |
Q3U1U8
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UniProt Splice Variant |
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Entrez Gene |
56501
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UniGene |
Mm.418617
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RefSeq |
NP_062654
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MGI ID |
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MGI Symbol |
Elf4
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OMIM |
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CCDS |
CCDS30108
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HPRD |
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IMGT |
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EMBL |
AF016714
AK155709
AL669901
AL844594
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GenPept |
AAD01601
BAE33395
CAM18942
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