InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rnf139

Summary

InnateDB Protein

IDBP-143607.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rnf139

Protein Name

ring finger protein 139

Synonyms

4930555P18Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000046467

InnateDB Gene

IDBG-143605 (Rnf139)

Protein Structure

UniProt Annotation

Function

E3-ubiquitin ligase; acts as a negative regulator of the cell proliferation through mechanisms involving G2/M arrest and cell death. Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER). Affects SREBP processing by hindering the SREBP/SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression. Required for INSIG1 ubiquitination. May be required for EIF3 complex ubiquitination. May function as a signaling receptor (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019787	small conjugating protein ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0008285	negative regulation of cell proliferation
GO:0016567	protein ubiquitination
GO:0017148	negative regulation of translation
GO:0031396	regulation of protein ubiquitination
GO:0060628	regulation of ER to Golgi vesicle-mediated transport
GO:0070613	regulation of protein processing