Version 5.4
Mus musculus Protein: Fam168b
Summary
InnateDB Protein IDBP-143623.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fam168b
Protein Name family with sequence similarity 168, member B
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000042212
InnateDB Gene IDBG-143621 (Fam168b)
Protein Structure
UniProt Annotation
Function Inhibitor of neuronal axonal outgrowth. Acts as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27. {ECO:0000269PubMed:20716133}.
Subcellular Localization Cytoplasm, perinuclear region {ECO:0000250}. Cell membrane {ECO:0000269PubMed:20716133}; Multi-pass membrane protein {ECO:0000269PubMed:20716133}. Cell projection, axon {ECO:0000269PubMed:20716133}. Note=Expressed in neuronal cell bodies and axonal fibers.
Disease Associations
Tissue Specificity Predominantly expressed in the brain, including olfactory bulb, cortex and cerebellum (at protein level). {ECO:0000269PubMed:20716133}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005575 cellular_component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0030424 axon
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID MGI:2448487
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q80XQ8
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 214469
UniGene Mm.411079
RefSeq NP_778162
MGI ID
MGI Symbol Fam168b
OMIM
CCDS CCDS14873
HPRD
IMGT
EMBL AK144298 AK220453 BC040511 BC043098 BC059247
GenPept AAH40511 AAH43098 AAH59247 BAD90278 BAE25820

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca