InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Grhpr

Summary

InnateDB Protein

IDBP-143635.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Grhpr

Protein Name

glyoxylate reductase/hydroxypyruvate reductase

Synonyms

1110059D05Rik; 6430629L09Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000047218

InnateDB Gene

IDBG-143633 (Grhpr)

Protein Structure

UniProt Annotation

Function

Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity
GO:0008465	glycerate dehydrogenase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0016618	hydroxypyruvate reductase activity
GO:0030267	glyoxylate reductase (NADP) activity
GO:0031406	carboxylic acid binding
GO:0042803	protein homodimerization activity
GO:0050661	NADP binding
GO:0051287	NAD binding
GO:0070402	NADPH binding

Biological Process

GO:0006098	pentose-phosphate shunt
GO:0007588	excretion
GO:0008152	metabolic process
GO:0043648	dicarboxylic acid metabolic process
GO:0051259	protein oligomerization
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1923488

InterPro

IPR006115 6-phosphogluconate dehydrogenase, NADP-binding
IPR006139 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding
IPR028939 Pyrroline-5-carboxylate reductase, catalytic, N-terminal

PFAM

PF03446
PF00389
PF02826
PF03807

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q91Z53

PhosphoSite