Version 5.4
Mus musculus Protein: Cldn6
Summary
InnateDB Protein IDBP-143727.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cldn6
Protein Name claudin 6
Synonyms AL024037;
Species Mus musculus
Ensembl Protein ENSMUSP00000024699
InnateDB Gene IDBG-143725 (Cldn6)
Protein Structure
UniProt Annotation
Function Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. {ECO:0000250}.
Subcellular Localization Cell junction, tight junction {ECO:0000269PubMed:9892664}. Cell membrane {ECO:0000269PubMed:9892664}; Multi-pass membrane protein {ECO:0000269PubMed:9892664}.
Disease Associations
Tissue Specificity Expressed mostly in embryonic tissues. {ECO:0000269PubMed:9892664}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0016338 calcium-independent cell-cell adhesion
GO:0045216 cell-cell junction organization
Cellular Component
GO:0005886 plasma membrane
GO:0005923 tight junction
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1859284
InterPro IPR003925 Claudin-6
IPR004031 PMP-22/EMP/MP20/Claudin superfamily
IPR006187 Claudin
PFAM PF00822
PF13903
PRINTS PR01445
PR01077
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Z262
PhosphoSite PhosphoSite-Q9Z262
TrEMBL Q0GH64
UniProt Splice Variant
Entrez Gene 54419
UniGene Mm.86421
RefSeq NP_061247
MGI ID
MGI Symbol Cldn6
OMIM
CCDS CCDS28457
HPRD
IMGT
EMBL AF087824 AF125305 AK010560 AK010682 BC005718 CH466606 DQ864649
GenPept AAD09759 AAH05718 AAK02012 ABI18968 BAB27028 BAB27114 EDL22262

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca