InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Uggt1

Summary

InnateDB Protein

IDBP-143763.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Uggt1

Protein Name

UDP-glucose glycoprotein glucosyltransferase 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000037930

InnateDB Gene

IDBG-143759 (Uggt1)

Protein Structure

UniProt Annotation

Function

Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum lumen {ECO:0000250UniProtKB:Q9NYU2, ECO:0000255PROSITE- ProRule:PRU10138}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000255PROSITE-ProRule:PRU10138}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003980	UDP-glucose:glycoprotein glucosyltransferase activity
GO:0005515	protein binding
GO:0051082	unfolded protein binding

Biological Process

GO:0006486	protein glycosylation
GO:0097359	UDP-glucosylation

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0070062	extracellular vesicular exosome