Version 5.4
Mus musculus Protein: Anln
Summary
InnateDB Protein IDBP-143785.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Anln
Protein Name anillin, actin binding protein
Synonyms 1110037A17Rik; 2900037I21Rik; C78101; Scraps;
Species Mus musculus
Ensembl Protein ENSMUSP00000045873
InnateDB Gene IDBG-143783 (Anln)
Protein Structure
UniProt Annotation
Function Required for cytokinesis. Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Note=Mainly found in the nucleus during interphase. Colocalizes with cortical F-actin upon nuclear envelope breakdown in mitosis and subsequently concentrates in the area of the prospective contractile ring in anaphase. This pattern persists until telophase, when the protein becomes concentrated in the midbody.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
Biological Process
GO:0000281 mitotic cytokinesis
GO:0002244 hematopoietic progenitor cell differentiation
GO:0007067 mitotic nuclear division
Cellular Component
GO:0005634 nucleus
GO:0005826 actomyosin contractile ring
GO:0015629 actin cytoskeleton
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID MGI:1920174
InterPro IPR001849 Pleckstrin homology domain
PFAM PF00169
PRINTS
PIRSF
SMART SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8K298
PhosphoSite PhosphoSite-Q8K298
TrEMBL
UniProt Splice Variant
Entrez Gene 68743
UniGene Mm.409363
RefSeq NP_082666
MGI ID
MGI Symbol Anln
OMIM
CCDS CCDS22927
HPRD
IMGT
EMBL AK013624 AK045703 AK046102 BC030489 BC032164
GenPept AAH30489 AAH32164 BAB28931 BAC32464 BAC32605

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca