InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Polr1e

Summary

InnateDB Protein

IDBP-143812.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Polr1e

Protein Name

polymerase (RNA) I polypeptide E

Synonyms

53kDa; AU042259; D030019D19Rik; Paf53; Praf1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029999

InnateDB Gene

IDBG-143810 (Polr1e)

Protein Structure

UniProt Annotation

Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Appears to be involved in the formation of the initiation complex at the promoter by mediating the interaction between Pol I and UBTF/UBF. {ECO:0000269PubMed:8641287, ECO:0000269PubMed:9254723}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000269PubMed:8641287, ECO:0000269PubMed:9254723}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001054	RNA polymerase I activity
GO:0001179	RNA polymerase I transcription factor binding
GO:0003677	DNA binding
GO:0003899	DNA-directed RNA polymerase activity
GO:0005515	protein binding

Biological Process

GO:0001189	RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript
GO:0006351	transcription, DNA-templated

Cellular Component