Version 5.4
| Mus musculus Protein: Fbxo10 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-143898.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Fbxo10 | ||||||||
| Protein Name | F-box protein 10 | ||||||||
| Synonyms | |||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000058233 | ||||||||
| InnateDB Gene | IDBG-143896 (Fbxo10) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. The SCF(FBXO10) complex mediates ubiquitination and degradation of BCL2, an antiapoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2 (By similarity). {ECO:0000250}. | ||||||||
| Subcellular Localization | Cytoplasm {ECO:0000250}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | |||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:2686937 | ||||||||
| InterPro |
IPR001810
F-box domain IPR006626 Parallel beta-helix repeat IPR006633 Carbohydrate-binding/sugar hydrolysis domain IPR011050 Pectin lyase fold/virulence factor IPR022441 Parallel beta-helix repeat-2 |
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| PFAM |
PF00646
PF12937 PF13013 |
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| PRINTS | |||||||||
| PIRSF | |||||||||
| SMART |
SM00256
SM00710 SM00722 |
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q7TQF2 | ||||||||
| PhosphoSite | PhosphoSite-Q7TQF2 | ||||||||
| TrEMBL | Q505G2 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 269529 | ||||||||
| UniGene | Mm.490989 | ||||||||
| RefSeq | NP_001019313 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Fbxo10 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS51171 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AL824706 BC052485 BC054731 BC079571 BC094565 | ||||||||
| GenPept | AAH52485 AAH54731 AAH79571 AAH94565 CAM17797 | ||||||||