Mus musculus Protein: Fbxo10
Summary
InnateDB Protein IDBP-143898.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fbxo10
Protein Name F-box protein 10
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000058233
InnateDB Gene IDBG-143896 (Fbxo10)
Protein Structure
UniProt Annotation
Function Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. The SCF(FBXO10) complex mediates ubiquitination and degradation of BCL2, an antiapoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2 (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0006915 apoptotic process
GO:0016567 protein ubiquitination
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0042981 regulation of apoptotic process
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:2686937
InterPro IPR001810 F-box domain
IPR006626 Parallel beta-helix repeat
IPR006633 Carbohydrate-binding/sugar hydrolysis domain
IPR011050 Pectin lyase fold/virulence factor
IPR022441 Parallel beta-helix repeat-2
PFAM PF00646
PF12937
PF13013
PRINTS
PIRSF
SMART SM00256
SM00710
SM00722
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7TQF2
PhosphoSite PhosphoSite-Q7TQF2
TrEMBL Q505G2
UniProt Splice Variant
Entrez Gene 269529
UniGene Mm.490989
RefSeq NP_001019313
MGI ID
MGI Symbol Fbxo10
OMIM
CCDS CCDS51171
HPRD
IMGT
EMBL AL824706 BC052485 BC054731 BC079571 BC094565
GenPept AAH52485 AAH54731 AAH79571 AAH94565 CAM17797