InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Paxip1

Summary

InnateDB Protein

IDBP-143922.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Paxip1

Protein Name

PAX interacting (with transcription-activation domain) protein 1

Synonyms

D5Ertd149e; PTIP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000002291

InnateDB Gene

IDBG-143920 (Paxip1)

Protein Structure

UniProt Annotation

Function

Involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. Plays a role in early development. In DNA damage response is required for cell survival after ionizing radiation. In vitro shown to be involved in the homologous recombination mechanism for the repair of double-strand breaks (DSBs). Its localization to DNA damage foci requires Rnf8 and Ube2n. Recruits Tp53bp1 to DNA damage foci and, at least in particular repair processes, effective DNA damage response appears to require the association with Tp53bp1 phosphorylated by Atm. Together with Tp53bp1 regulates Atm association. Recruits Pagr1 to sites of DNA damage and the Pagr1:Paxip1 complex is required for cell survival in response to DNA damage; the function is probbaly independent of MLL-containing histone methyltransferase (HMT) complexes. Promotes ubiquitination of PCNA following UV irradiation and may regulate recruitment of polymerase eta and Rad51 to chromatin after DNA damage. Proposed to be involved in transcriptional regulation by linking MLL-containing histone methyltransferase (HMT) complexes to gene promoters by interacting with promoter-bound transcription factors such as Pax2. Associates with gene promoters that are known to be regulated by Kmt2d/Mll2. During immunoglobulin class switching in activated B-cells is involved in trimethylation of histone H3 at 'Lys-4' and in transcription initiation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus; this function appears to involve the recruitment of MLL- containing HMT complexes (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus matrix {ECO:0000269PubMed:10908331, ECO:0000269PubMed:19124460}.

Disease Associations

Tissue Specificity

Expression detected in all tissues examined, including brain stem, cerebellum, cortex, heart, spleen, kidney, liver, thymus and lung. {ECO:0000269PubMed:10908331}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 240 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	240 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000416	positive regulation of histone H3-K36 methylation
GO:0001570	vasculogenesis
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0006351	transcription, DNA-templated
GO:0006974	cellular response to DNA damage stimulus
GO:0010212	response to ionizing radiation
GO:0030330	DNA damage response, signal transduction by p53 class mediator
GO:0031398	positive regulation of protein ubiquitination
GO:0035066	positive regulation of histone acetylation
GO:0043542	endothelial cell migration
GO:0045830	positive regulation of isotype switching
GO:0051568	histone H3-K4 methylation
GO:0051571	positive regulation of histone H3-K4 methylation
GO:0060261	positive regulation of transcription initiation from RNA polymerase II promoter
GO:0060612	adipose tissue development
GO:0060717	chorion development