Version 5.4
Mus musculus Protein: Pole2
Summary
InnateDB Protein IDBP-143942.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pole2
Protein Name polymerase (DNA directed), epsilon 2 (p59 subunit)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000021359
InnateDB Gene IDBG-143940 (Pole2)
Protein Structure
UniProt Annotation
Function Participates in DNA repair and in chromosomal DNA replication.
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-dependent DNA replication
Cellular Component
GO:0005634 nucleus
GO:0008622 epsilon DNA polymerase complex
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID MGI:1197514
InterPro IPR007185 DNA polymerase alpha/epsilon, subunit B
IPR016266 DNA polymerase epsilon, subunit B
IPR024639 DNA polymerase epsilon subunit B, N-terminal
PFAM PF04042
PF12213
PRINTS
PIRSF PIRSF000799
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O54956
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 18974
UniGene Mm.9199
RefSeq NP_035263
MGI ID
MGI Symbol Pole2
OMIM
CCDS CCDS36463
HPRD
IMGT
EMBL AF036898 AK077592 BC063772
GenPept AAC40045 AAH63772 BAC36883

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca