InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hs3st5

Summary

InnateDB Protein

IDBP-143967.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hs3st5

Protein Name

heparan sulfate (glucosamine) 3-O-sulfotransferase 5

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000060229

InnateDB Gene

IDBG-143965 (Hs3st5)

Protein Structure

UniProt Annotation

Function

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site. Also generates GlcUA- GlcNS or IdoUA-GlcNS and IdoUA2S-GlcNH2 (By similarity). {ECO:0000250}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008146	sulfotransferase activity
GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity

Biological Process

GO:0006477	protein sulfation
GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification
GO:0046596	regulation of viral entry into host cell
GO:0050819	negative regulation of coagulation